Tissue Factor and Thrombosis Models

Tissue factor and thrombosis models.

Mouse models of thrombosis have extended our understanding of the role of tissue factor (TF) in thrombogenesis. Because tissue factor deficiency is embryonic lethal in mice, inventive genetic models are required to probe the role of TF in thrombosis. TF is expressed by different cell types, including vascular smooth muscle cells, cardiomyocytes, fibroblasts, and monocytes. Platelets and endothe...

Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit.

Tissue factor (TF) plays a role in thrombogenesis. TF initiates blood coagulation resulting in the generation of protease coagulant mediators (FVIIa, FXa, and FIIa) and fibrin production. TF hypercoagulablility directly contributes to thrombus formation resulting from the major events of fibrin deposition and FIIa-induced platelet activation/aggregation. In addition, blood coagulation indirectl...

Uremic Serum and Ubiquitylation of Tissue Factor Running title: Mackman; Tissue factor and stent thrombosis

Tissue Factor Overexpression in Rat Arterial Neointima Models Thrombosis and Progression of Advanced Atherosclerosis

Progression of Advanced Atherosclerosis Tissue Factor Overexpression in Rat Arterial Neointima Models Thrombosis and Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.22.2651 2000;101:2651-2657 Circulation...

Tissue factor overexpression in rat arterial neointima models: thrombosis and progression of advanced atherosclerosis.

BACKGROUND Tissue factor located in the atherosclerotic plaque might cause the clinically significant thrombotic events associated with end-stage disease. It might also affect intimal area by increasing matrix accumulation and stimulating smooth muscle cell (SMC) migration and proliferation. To test this hypothesis, we overexpressed tissue factor in a rat model of the human fibrous plaque. ME...